Asymmetric alkylation reaction of α-fluorotetralone under phase-transfer catalyzed conditions

被引：50

作者：

Arai, S ^{[1
]}

Oku, M

Ishida, T

Shioiri, T

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691041, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 37期

关键词：

alkylation; asymmetric synthesis; catalysts; phase transfer;

D O I：

10.1016/S0040-4039(99)01282-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic asymmetric alkylation reaction of alpha-fluorotetralones promoted by a chiral quaternary ammonium salt derived from cinchonine under phase-transfer catalyzed conditions was described. The reaction proceeded smoothly to give the desired products with up to 91% ee. This methodology provides a practical protocol for the preparation of optically active fluoro compounds on a large scale. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6785 / 6789

页数：5

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