Genome Architecture: Domain Organization of Interphase Chromosomes

被引：518

作者：

Bickmore, Wendy A. ^{[1
]}

van Steensel, Bas ^{[2
]}

机构：

[1] Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands

来源：

CELL | 2013年 / 152卷 / 06期

关键词：

EMBRYONIC STEM-CELLS; NUCLEAR LAMINA INTERACTIONS; RANGE DNA INTERACTIONS; GENE-EXPRESSION; DROSOPHILA GENOME; CHROMATIN DOMAINS; 3-DIMENSIONAL ARCHITECTURE; SPATIAL-ORGANIZATION; TRANSCRIPTOME MAP; X-INACTIVATION;

D O I：

10.1016/j.cell.2013.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.

引用

页码：1270 / 1284

页数：15

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