A synthesis of camptothecin

被引：38

作者：

Chavan, SP ^{[1
]}

Sivappa, R ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 15期

关键词：

camptothecin; total synthesis; tandem reductive amination-michael addition; ketol;

D O I：

10.1016/j.tetlet.2004.02.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of camptothecin has been carried out. Central to our synthesis is the intramolecular condensation of a suitably designed ketol, which in turn was obtained from a tricyclic ABC ring synthon. A tandem reductive animation and Michael addition sequence on an unsaturated quinoline ester was employed for the assembly of the ABC skeleton. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3113 / 3115

页数：3

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