A sweet spot for the bariatric surgeon

被引:16
作者
Perez-Tilve, Diego [1 ,2 ]
D'Alessio, David A. [1 ,2 ]
Tschoep, Matthias H. [1 ,2 ]
机构
[1] Univ Cincinnati, Sch Med, Obes Res Ctr, Dept Psychiat, Cincinnati, OH 45267 USA
[2] Univ Cincinnati, Sch Med, Obes Res Ctr, Dept Med, Cincinnati, OH 45267 USA
关键词
D O I
10.1016/j.cmet.2008.08.012
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
While gastric bypass surgery remains popular as the only treatment for morbid obesity with curative potential, the molecular mechanisms underpinning its immediate metabolic benefits remain unclear. New work in this issue (Troy et al., 2008) suggests intestinal glucose production sensed by afferent nerve fibers surrounding the portal vein may be key.
引用
收藏
页码:177 / 179
页数:3
相关论文
共 10 条
[1]   Long-term mortality after gastric bypass surgery [J].
Adams, Ted D. ;
Gress, Richard E. ;
Smith, Sherman C. ;
Halverson, R. Chad ;
Simper, Steven C. ;
Rosamond, Wayne D. ;
LaMonte, Michael J. ;
Stroup, Antoinette M. ;
Hunt, Steven C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (08) :753-761
[2]   The vagus nerve, food intake and obesity [J].
Berthoud, Hans-Rudolf .
REGULATORY PEPTIDES, 2008, 149 (1-3) :15-25
[3]   Bypassing medicine to treat diabetes [J].
Couzin, Jennifer .
SCIENCE, 2008, 320 (5875) :438-440
[4]   Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein [J].
Mithieux, G ;
Misery, P ;
Magnan, C ;
Pillot, B ;
Gautier-Stein, A ;
Bernard, C ;
Rajas, F ;
Zitoun, C .
CELL METABOLISM, 2005, 2 (05) :321-329
[5]   WHO WOULD HAVE THOUGHT IT - AN OPERATION PROVES TO BE THE MOST EFFECTIVE THERAPY FOR ADULT-ONSET DIABETES-MELLITUS [J].
PORIES, WJ ;
SWANSON, MS ;
MACDONALD, KG ;
LONG, SB ;
MORRIS, PG ;
BROWN, BM ;
BARAKAT, HA ;
DERAMON, RA ;
ISRAEL, G ;
DOLEZAL, JM ;
DOHM, L .
ANNALS OF SURGERY, 1995, 222 (03) :339-352
[6]   THE CONTROL OF DIABETES-MELLITUS (NIDDM) IN THE MORBIDLY OBESE WITH THE GREENVILLE GASTRIC BYPASS [J].
PORIES, WJ ;
CARO, JF ;
FLICKINGER, EG ;
MEELHEIM, HD ;
SWANSON, MS .
ANNALS OF SURGERY, 1987, 206 (03) :316-323
[7]   The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes [J].
Rubino, Francesco ;
Forgione, Antonello ;
Cummings, David E. ;
Vix, Michel ;
Gnuli, Donatella ;
Mingrone, Geltrude ;
Castagneto, Marco ;
Marescaux, Jacques .
ANNALS OF SURGERY, 2006, 244 (05) :741-749
[8]   Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery [J].
Service, GJ ;
Thompson, GB ;
Service, FJ ;
Andrews, JC ;
Collazo-Clavell, ML ;
Lloyd, RV .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (03) :249-254
[9]   Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice [J].
Troy, Stephanie ;
Soty, Maud ;
Ribeiro, Lara ;
Laval, Laure ;
Migrenne, Stephanie ;
Fioramonti, Xavier ;
Pillot, Bruno ;
Fauveau, Veronique ;
Aubert, Roberte ;
Viollet, Benoit ;
Foretz, Marc ;
Leclerc, Jocelyne ;
Duchampt, Adeline ;
Zitoun, Carine ;
Thorens, Bernard ;
Magnan, Christophe ;
Mithieux, Gilles ;
Andreelli, Fabrizio .
CELL METABOLISM, 2008, 8 (03) :201-211
[10]   Changes in gut hormones after bariatric surgery [J].
Vincent, R. P. ;
le Roux, C. W. .
CLINICAL ENDOCRINOLOGY, 2008, 69 (02) :173-179