Regulation of Spermatogonial Stem Cell Self-Renewal in Mammals

被引：408

作者：

Oatley, Jon A. ^{[1
]}

Brinster, Ralph L. ^{[2
]}

机构：

[1] Penn State Univ, Coll Agr Sci, Dept Anim Sci, Ctr Reprod Biol & Hlth, University Pk, PA 16802 USA

[2] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2008年 / 24卷

关键词：

rodent; stem cell niche; testis; GDNF; transcription factor;

D O I：

10.1146/annurev.cellbio.24.110707.175355

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian spermatogenesis is a classic adult stem cell-dependent process, supported by self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs provides a model to better understand adult stein cell biology, and deciphering the mechanisms that control SSC functions may lead to treatment of male infertility and all understanding of the etiology of testicular germ cell tumor formation. Self-renewal of rodent SSCs is greatly influenced by the niche factor glial cell line-derived neurotrophic factor (GDNF). In mouse SSCs, GDNT activation upregulates expression of the transcription factor-encoding genes bcl6b, etv5, mid lhx1, which influence SSC self-renewal. Addition, the non-GDNF-stimulated transcription factors Plzf and Taf4b been implicated in regulating SSC functions. Together these molecules are part of a robust gene network controlling SSC fate decisions that may parallel the regulatory networks in other adult stem cell populations.

引用

页码：263 / 286

页数：24

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