Scaffolds for liver tissue engineering

被引:44
作者
Hammond, John S.
Beckingham, Ian J.
Shakesheff, Kevin M.
机构
[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England
[2] Univ Nottingham Hosp, Dept Surg, Nottingham NG7 2UH, England
关键词
biomaterials; liver regeneration; liver tissue engineering; scaffolds;
D O I
10.1586/17434440.3.1.21
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This review focuses on the expanding role for biomaterials and polymer scaffolds in liver tissue engineering. Studies are subdivided into in vitro and in vivo approaches. The in vitro section of the review discusses the challenges specific to liver tissue engineering, and how the choice of scaffold and its structure influences the success of the regenerative medicine strategy. The in vivo section evaluates early attempts to stimulate liver repair with cell and growth factor therapies, their failings and how current approaches aim to solve these problems.
引用
收藏
页码:21 / 27
页数:7
相关论文
共 73 条
[11]   TRANSPLANTATION OF MICROCARRIER-ATTACHED HEPATOCYTES INTO 90-PERCENT PARTIALLY HEPATECTOMIZED RATS [J].
DEMETRIOU, AA ;
REISNER, A ;
SANCHEZ, J ;
LEVENSON, SM ;
MOSCIONI, AD ;
CHOWDHURY, JR .
HEPATOLOGY, 1988, 8 (05) :1006-1009
[12]   REPLACEMENT OF LIVER-FUNCTION IN RATS BY TRANSPLANTATION OF MICROCARRIER-ATTACHED HEPATOCYTES [J].
DEMETRIOU, AA ;
WHITING, JF ;
FELDMAN, D ;
LEVENSON, SM ;
CHOWDHURY, NR ;
MOSCIONI, AD ;
KRAM, M ;
CHOWDHURY, JR .
SCIENCE, 1986, 233 (4769) :1190-1192
[13]   Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure [J].
Demetriou, AA ;
Brown, RS ;
Busuttil, RW ;
Fair, J ;
McGuire, BM ;
Rosenthal, P ;
Esch, JSA ;
Lerut, J ;
Nyberg, SL ;
Salizzoni, M ;
Fagan, EA ;
de Hemptinne, B ;
Broelsch, CE ;
Muraca, M ;
Salmeron, JM ;
Rabkin, JM ;
Metselaar, HJ ;
Pratt, D ;
De La Mata, M ;
McChesney, LP ;
Everson, GT ;
Lavin, PT ;
Stevens, AC ;
Pitkin, Z ;
Solomon, BA .
ANNALS OF SURGERY, 2004, 239 (05) :660-667
[14]   LONG-TERM INVITRO FUNCTION OF ADULT HEPATOCYTES IN A COLLAGEN SANDWICH CONFIGURATION [J].
DUNN, JCY ;
TOMPKINS, RG ;
YARMUSH, ML .
BIOTECHNOLOGY PROGRESS, 1991, 7 (03) :237-245
[15]   Liver tissue engineering within alginate scaffolds: Effects of cell-seeding density on hepatocyte viability, morphology, and function [J].
Dvir-Ginzberg, M ;
Gamlieli-Bonshtein, I ;
Agbaria, R ;
Cohen, S .
TISSUE ENGINEERING, 2003, 9 (04) :757-766
[16]   Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells [J].
Fausto, N .
HEPATOLOGY, 2004, 39 (06) :1477-1487
[17]   Hepatic stem cells [J].
Forbes, S ;
Vig, P ;
Poulsom, R ;
Thomas, H ;
Alison, M .
JOURNAL OF PATHOLOGY, 2002, 197 (04) :510-518
[18]   Hepatocyte transplantation [J].
Fox, IJ ;
Roy-Chowdhury, J .
JOURNAL OF HEPATOLOGY, 2004, 40 (06) :878-886
[19]   Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres [J].
Fu, K ;
Pack, DW ;
Klibanov, AM ;
Langer, R .
PHARMACEUTICAL RESEARCH, 2000, 17 (01) :100-106
[20]   Comparison of hollow fibre membranes for hepatocyte immobilisation in bioreactors [J].
Gerlach, JC ;
Schnoy, N ;
Vienken, J ;
Smith, M ;
Neuhaus, P .
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1996, 19 (10) :610-616