An efficient and metal free synthesis of benzylpyridines using HI through the deoxygenation reaction

被引：11

作者：

Chandrasekar, Selvaraj ^{[1
]}

Karthikeyan, Iyyanar ^{[1
]}

Sekar, Govindasamy ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 72期

关键词：

HIV-1; INTEGRASE; REDUCTION; HALIDES; ACID; INHIBITORS; COUPLINGS; OXIDATION; PYRIDINES; ALCOHOLS;

D O I：

10.1039/c5ra09257d

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

An efficient and practical method for the synthesis of benzylpyridine derivatives has been developed using aqueous hydroiodic acid in acetic acid. This method is also successfully applied for the synthesis of 2,6-disubstituted pyridine derivatives under the same reaction conditions. Using readily available aqueous hydroiodic acid as a reducing agent made this process economical. When the aryl group of the secondary alcohol is replaced by an alkyl group, the reaction gives exclusively an acetoxylation instead of deoxygenation reaction.

引用

页码：58790 / 58797

页数：8

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