Palladium-Catalyzed Benzylic Arylation of 2-Methyl Azaarenes

被引：71

作者：

Burton, Paul M. ^{[1
]}

Morris, James A. ^{[1
]}

机构：

[1] Syngenta Ltd, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 23期

关键词：

SITE-SELECTIVE SP(2); C-H BONDS; ARYL HALIDES; BASE;

D O I：

10.1021/ol102276e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed benzylic sp(3) direct arylation of electron-deficient heterocycles is reported. The method described enables the introduction of electron-rich and -poor aromatics at the benzylic position of heterocycles without the need for preactivation or the use of directing groups.

引用

页码：5359 / 5361

页数：3

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