Palladium-catalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids

被引:653
作者
Giri, Ramesh [1 ]
Maugel, Nathan [1 ]
Li, Jiao-Jie [1 ]
Wang, Dong-Hui [1 ]
Breazzano, Steven P. [1 ]
Saunders, Lindsey B. [1 ]
Yu, Jin-Quan [1 ]
机构
[1] Brandeis Univ, Dept Chem MS015, Waltham, MA 02454 USA
基金
美国国家科学基金会;
关键词
D O I
10.1021/ja0701614
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The use of preformed sodium carboxylates as substrates led to the first observation of facile Pd-insertions into sp(3) beta-C-H bonds in simple aliphatic acids. Consequently, Pd-catalyzed methylation and arylation of o-C-H bonds in benzoic acids and beta-C-H bonds in aliphatic acids using either a phenylboronate, methylboronic acid, or ArI have been achieved via a C-H activation/C-C coupling sequence.
引用
收藏
页码:3510 / +
页数:3
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