Sulfoxide-mediated diastereoselective Michael additions. New enantioselective synthesis of C-4 substituted 2-pyroaminoadipic acids

被引：8

作者：

Acherki, H ^{[1
]}

Alvarez-Ibarra, C ^{[1
]}

Barrasa, A ^{[1
]}

de Dios, A ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Quim, Dept Quim Organ 1, E-28040 Madrid, Spain

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 31期

关键词：

amino acids and derivatives; sulfoxides; Michael reactions; asymmetric induction;

D O I：

10.1016/S0040-4039(99)01047-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective reactions of suitably functionalized homochiral beta-iminosulfoxides with Michael accepters provide a new and efficient route for the asymmetric synthesis of C-4 substituted 2-pyroaminoadipates. Extension of the scope of the sulfoxide-mediated aza-enolate conjugate addition (Hua's reaction) has also been explored. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5763 / 5766

页数：4

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