Interspecies transmission and emergence of novel viruses: lessons from bats and birds

被引:382
作者
Chan, Jasper Fuk-Woo [1 ,2 ,3 ,4 ]
To, Kelvin Kai-Wang [1 ,2 ,3 ,4 ]
Tse, Herman [1 ,2 ,3 ,4 ]
Jin, Dong-Yan [5 ]
Yuen, Kwok-Yung [1 ,2 ,3 ,4 ]
机构
[1] Univ Hong Kong, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Carol Yu Ctr Infect, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Res Ctr Infect & Immunol, Hong Kong, Hong Kong, Peoples R China
[4] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
[5] Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
关键词
coronavirus; influenza; RNA virus; virus evolution; emerging infectious disease; INFLUENZA-A VIRUS; RESPIRATORY SYNDROME CORONAVIRUS; MOLECULAR-CLONING; RECEPTOR-BINDING; H5N1; INFLUENZA; RIG-I; AVIAN CORONAVIRUSES; EXPRESSION ANALYSIS; DIFFERENT STRAINS; HUMAN INFECTIONS;
D O I
10.1016/j.tim.2013.05.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As exemplified by coronaviruses and influenza viruses, bats and birds are natural reservoirs for providing viral genes during evolution of new virus species and viruses for interspecies transmission. These warm-blooded vertebrates display high species biodiversity, roosting and migratory behavior, and a unique adaptive immune system, which are favorable characteristics for asymptomatic shedding, dissemination, and mixing of different viruses for the generation of novel mutant, recombinant, or reassortant RNA viruses. The increased intrusion of humans into wildlife habitats and overcrowding of different wildlife species in wet markets and farms have also facilitated the interspecies transmission between different animal species.
引用
收藏
页码:544 / 555
页数:12
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