What controls TOR?

被引：32

作者：

Jacinto, Estela ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA

来源：

IUBMB LIFE | 2008年 / 60卷 / 08期

关键词：

enzyme mechanisms; eukaryotic gene expression; molecular genetics; phosphoinositides; protein function; protein synthesis; signal transduction;

D O I：

10.1002/iub.56

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The target of rapamycin (TOR) is a protein kinase with numerous functions in cell growth control. Some of these functions can be potently inhibited by rapamycin, an immunosuppressive and potential anticancer drug. TOR exists as part of two functionally distinct protein complexes. The functions of TOR complex 1 (TORC1) are effectively inhibited by rapamycin, but the mechanism for this inhibition remains elusive. The identification of TORC2 and recent reports that rapamycin can inhibit TORC2 functions, in some cases, challenge current models of TOR regulation. This review discusses the latest findings in yeast and mammals on the possible mechanisms that control TOR activity leading to its many cellular functions. (c) 2008 IUBMB.

引用

收藏

页码：483 / 496

页数：14

相关论文

共 143 条

[91] TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases [J].

Petersen, Janni ;

Nurse, Paul .

NATURE CELL BIOLOGY, 2007, 9 (11) :1263-U97

[92] FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions [J].

Peterson, RT ;

Beal, PA ;

Comb, MJ ;

Schreiber, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (10) :7416-7423

[93] Translation control: Connecting mitogens and the ribosome [J].

Peterson, RT ;

Schreiber, SL .

CURRENT BIOLOGY, 1998, 8 (07) :R248-+

[94] TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae [J].

Reinke, A ;

Anderson, S ;

McCaffery, JM ;

Yates, J ;

Aronova, S ;

Chu, S ;

Fairclough, S ;

Iverson, C ;

Wedaman, KP ;

Powers, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :14752-14762

[95]

Roberg KJ, 1997, GENETICS, V147, P1569

[96] Regulation of the small GTPase Rheb by amino acids [J].

Roccio, M ;

Bos, JL ;

Zwartkruis, FJT .

ONCOGENE, 2006, 25 (05) :657-664

[97] Insulin regulation of a novel WD-40 repeat protein in adipocytes [J].

Rodgers, BD ;

Levine, MA ;

Bernier, M ;

Montrose-Rafizadeh, C .

JOURNAL OF ENDOCRINOLOGY, 2001, 168 (02) :325-332

[98] Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9 [J].

Roelants, FM ;

Torrance, PD ;

Thorner, J .

MICROBIOLOGY-SGM, 2004, 150 :3289-3304

[99] Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase [J].

Roux, PP ;

Ballif, BA ;

Anjum, R ;

Gygi, SP ;

Blenis, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (37) :13489-13494

[100] Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins [J].

Rudra, D ;

Zhao, Y ;

Warner, JR .

EMBO JOURNAL, 2005, 24 (03) :533-542

← 5 6 7 8 9 10 11 12 13 14 →