Translation control: Connecting mitogens and the ribosome

被引:130
作者
Peterson, RT [1 ]
Schreiber, SL
机构
[1] Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA
[2] Harvard Univ, Howard Hughes Med Inst, Dept Cellular & Mol Biol, Cambridge, MA 02138 USA
关键词
D O I
10.1016/S0960-9822(98)70152-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The identification of 3-phosphoinositide-dependent kinase 1 (PDK1) as one of the elusive 70 kDa S6 kinase kinases has filled a gap in the signaling pathway by which extracellular receptors regulate translation. Will it cause us to reconsider the relationships between previously identified members of the pathway?
引用
收藏
页码:R248 / +
页数:4
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