Genenames.org: the HGNC and VGNC resources in 2019

被引：220

作者：

Braschi, Bryony ^{[1
]}

Denny, Paul ^{[1
]}

Gray, Kristian ^{[1
]}

Jones, Tamsin ^{[1
]}

Seal, Ruth ^{[1
]}

Tweedie, Susan ^{[1
]}

Yates, Bethan ^{[1
]}

Bruford, Elspeth ^{[1
]}

机构：

[1] European Bioinformat Inst, European Mol Biol Lab, HUGO Gene Nomenclature Comm, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

基金：

英国惠康基金;

关键词：

INFORMATION RESOURCE; DATABASE; SEQUENCE; GENE;

D O I：

10.1093/nar/gky930

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 to assign standardized nomenclature in line with human for vertebrate species that lack their own nomenclature committees. The VGNC initially assigned nomenclature for over 15000 protein-coding genes in chimpanzee. We have extended this process to other vertebrate species, naming over 14000 protein-coding genes in cow and dog and over 13 000 in horse to date. Our HGNC website https://www.genenames.org has undergone a major design update, simplifying the homepage to provide easy access to our search tools and making the site more mobile friendly. Our gene families pages are now known as gene groups' and have increased in number to over 1200, with nearly half of all named genes currently assigned to at least one gene group. This article provides an overview of our online data and resources, focusing on our work over the last two years.

引用

页码：D786 / D792

页数：7

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