Transcriptional Scaffolds for Heterochromatin Assembly

被引：63

作者：

Cam, Hugh P. ^{[1
]}

Chen, Ee Sin ^{[1
]}

Grewal, Shiv I. S. ^{[1
]}

机构：

[1] NCI, Biochem & Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2009年 / 136卷 / 04期

关键词：

RNA; CHROMATIN; COMPLEX; GENES; ROLES;

D O I：

10.1016/j.cell.2009.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Heterochromatin is dynamically regulated during the cell cycle and in response to developmental signals. Recent findings from diverse systems suggest an extensive role for transcription in the assembly of heterochromatin, highlighting the emerging theme that transcription and noncoding RNAs can provide the initial scaffold for the formation of heterochromatin, which serves as a versatile recruiting platform for diverse factors involved in many cellular processes.

引用

页码：610 / 614

页数：5

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