Novel C19 homolignans, taiwanschirin A, B, and cytotoxic taiwanschirin C, and a new C18 lignan, schizanrin A, from Schizandra arisanensis

被引：50

作者：

Kuo, YH ^{[1
]}

Huang, HC ^{[1
]}

Kuo, LMY ^{[1
]}

Chen, CF ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 19期

关键词：

D O I：

10.1021/jo990263f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel C-19 homolignans with a 3,4-pentano-2,3-dihydrobenzo[b]furan skeleton, taiwanschirin A (1), taiwanschirin B (2), and taiwanschirin C (3), and a new C-18 dibenzocyclooctadiene lignan, schizanrin A (4) were isolated from Schizandra arisanensis. Taiwanschirin C (3) and schizarin A (4) exhibited in vitro cytotoxicity against hepatoma (Hepa-3B, ED50 = 2.2 mu g/mL for 3, and ED50 = 4.2 mu g/mL for 4). Compound 4 also showed marginal activity against colon carcinoma (COLO-205, ED50 = 2.9 mu g/mL). Their structural elucidation by spectral and single-crystal X-ray analyses, and structure-activity relationships are discussed.

引用

页码：7023 / 7027

页数：5

共 15 条

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