An extremely high insulin-mimetic activity of bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex

被引：25

作者：

Katoh, A ^{[1
]}

Tsukahara, T

Saito, R

Ghosh, KK

Yoshikawa, Y

Kojima, Y

Tamura, A

Sakurai, H

机构：

[1] Seikei Univ, Fac Engn, Dept Appl Chem, Tokyo 1808633, Japan

[2] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan

[3] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Yamashina Ku, Kyoto 6078413, Japan

来源：

CHEMISTRY LETTERS | 2002年 / 01期

关键词：

D O I：

10.1246/cl.2002.114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vanadyl and zinc(II) complexes with VO(O2S2) and Zn(O2S2) coordination mode, respectively, were synthesized. Among them, bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex exhibited an extremely high insulin-mimetic activity (IC50 = 0.04 mM when IC50 value of a positive control, VOSO4 was estimated to be 1.0 mM) compared to vanadyl and zinc(II) complexes reported previously.

引用

页码：114 / 115

页数：2

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