Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: fluorescence properties of compact conjugated acetylenes containing a purine ring

被引：52

作者：

Firth, Andrew G.

Fairlamb, Ian J. S.

Darley, Kate

Baumann, Christoph G.

机构：

[1] Replizyme Ltd, York YO10 5DQ, N Yorkshire, England

[2] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[3] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 21期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2006.03.100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical Sonogashira alkynylation protocol for the preparation of 8-alkynylated adenosines and guanosines has been developed. Protection of the sugar hydroxyl substituents is not required; protection hinders the purification of these products. A preliminary fluorescent study is reported, which shows that the presence of a substituent on the phenylene ring influences the fluorescent properties considerably, an outcome that could be utilized in biological applications. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3529 / 3533

页数：5

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