Pd/C-mediated coupling of aryl halides with terminal alkynes in water

被引：55

作者：

Batchu, VR ^{[1
]}

Subramanian, V ^{[1
]}

Parasuraman, K ^{[1
]}

Swamy, NK ^{[1
]}

Kumar, S ^{[1
]}

Pal, M ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Chem Discovery Res, Hyderabad 500049, Andhra Pradesh, India

来源：

TETRAHEDRON | 2005年 / 61卷 / 41期

关键词：

aryl halides; palladium catalyst; 2-aminoethanol; aqueous media;

D O I：

10.1016/j.tet.2005.06.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminoethanol facilitated the alkynylation of aryl halides (Sonogashira reaction) under palladium/charcoal-copper catalysis in water affording a mild and practical method for the synthesis of arylalkynes. A variety of terminal alkynes were coupled with aryl iodides and bromides possessing no hydrophilic functional groups to give the coupled products in good to excellent yields. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：9869 / 9877

页数：9

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