Tumour necrosis factor, a key role in obesity?

被引：60

作者：

Bulló-Bonet, M

García-Lorda, P

López-Soriano, FJ

Argilés, JM

Salas-Salvadó, J

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Unit Bioquim & Biol Mol B, Barcelona 08071, Spain

[2] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unit Nutr Humana, E-43201 Reus, Spain

来源：

FEBS LETTERS | 1999年 / 451卷 / 03期

关键词：

TNF; insulin resistance; adipose tissue; obesity;

D O I：

10.1016/S0014-5793(99)00540-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumour necrosis factor-alpha (TNF) is a pleiotropic cytokine involved in many metabolic responses in both normal and pathophysiological states. In spite of the fact that this cytokine (also known as "cachectin") has been related to many of the metabolic abnormalities associated with cachexia, recent studies suggest that TNF may also have a central role in obesity modulating energy expenditure, fat deposition and insulin resistance, This review deals with the role of TNF in the control of fat mass and obesity. (C) 1999 Federation of European Biochemical Societies.

引用

页码：215 / 219

页数：5

共 72 条

[51]

Peschon JJ, 1998, J IMMUNOL, V160, P943

[52] Leptin receptor missense mutation in the fatty Zucker rat [J].