Determination of ginsenosides from Panax ginseng using micellar electrokinetic chromatography

被引：16

作者：

Glöckl, I

Veit, M

Blaschke, G

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

[2] Forschungsvereinigung Arzneimittel Hersteller eV, Sinzig, Germany

[3] Zentralinst Arzneimittelforsch GmbH, Sinzig, Germany

来源：

PLANTA MEDICA | 2002年 / 68卷 / 02期

关键词：

capillary electrophoresis; micellar electrokinetic chromatography; Panax ginseng; Araliaceae; ginsenosides; validation;

D O I：

10.1055/s-2002-20241

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A method for determination of ginsenosides in herbal medicinal products (HMPs) was developed using micellar electrokinetic chromatography (MEKC). Within 22 minutes 7 major ginsenosides were well separated. In order to demonstrate the accuracy, precision and robustness for the main target analyte the method was exemplarily validated for the determination of Rb-1 according to ICH guidelines. Compared to chromatographic analysis, several benefits of capillary electrophoresis (CE) could be demonstrated such as high separation efficiency in an aqueous buffer without any organic solvent and shorter run time per assay.

引用

页码：158 / 161

页数：4

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