The regulation and function of the NUAK family

被引：64

作者：

Sun, Xianglan ^{[1
]}

Gao, Ling ^{[2
]}

Chien, Hung-Yu ^{[3
]}

Li, Wan-Chun ^{[4
,5
]}

Zhao, Jiajun ^{[1
]}

机构：

[1] Shandong Univ, Dept Endocrinol, Jinan 250100, Peoples R China

[2] Shandong Univ, Cent Lab, Prov Hosp, Jinan 250100, Peoples R China

[3] Taipei City Hosp, Ren Ai Branch, Dept Endocrinol & Metab, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Oral Biol, Sch Dent, Dept Dent, Taipei 112, Taiwan

[5] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2013年 / 51卷 / 02期

关键词：

AMP-activated protein kinase (AMPK); AMPK-related kinase; NUAK family; LKB1; ARK5; sucrose-non-fermenting protein kinase (SNF1)/AMPK-related kinase (SNARK); ACTIVATED PROTEIN-KINASE; AMPK-RELATED KINASES; MOUSE SKELETAL-MUSCLE; SNARK-DEFICIENT MICE; CELL-DEATH; GLUCOSE STARVATION; UPSTREAM KINASE; TUMOR INVASION; EXPRESSION; ARK5;

D O I：

10.1530/JME-13-0063

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2.

引用

页码：R15 / R22

页数：8

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