The regulation and function of the NUAK family

被引：64

作者：

Sun, Xianglan ^{[1
]}

Gao, Ling ^{[2
]}

Chien, Hung-Yu ^{[3
]}

Li, Wan-Chun ^{[4
,5
]}

Zhao, Jiajun ^{[1
]}

机构：

[1] Shandong Univ, Dept Endocrinol, Jinan 250100, Peoples R China

[2] Shandong Univ, Cent Lab, Prov Hosp, Jinan 250100, Peoples R China

[3] Taipei City Hosp, Ren Ai Branch, Dept Endocrinol & Metab, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Oral Biol, Sch Dent, Dept Dent, Taipei 112, Taiwan

[5] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2013年 / 51卷 / 02期

关键词：

AMP-activated protein kinase (AMPK); AMPK-related kinase; NUAK family; LKB1; ARK5; sucrose-non-fermenting protein kinase (SNF1)/AMPK-related kinase (SNARK); ACTIVATED PROTEIN-KINASE; AMPK-RELATED KINASES; MOUSE SKELETAL-MUSCLE; SNARK-DEFICIENT MICE; CELL-DEATH; GLUCOSE STARVATION; UPSTREAM KINASE; TUMOR INVASION; EXPRESSION; ARK5;

D O I：

10.1530/JME-13-0063

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2.

引用

页码：R15 / R22

页数：8

共 52 条

[41] ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma [J].

Suzuki, A ;

Iida, S ;

Kato-Uranishi, M ;

Tajima, E ;

Zhan, FH ;

Hanamura, I ;

Huang, YS ;

Ogura, T ;

Takahashi, S ;

Ueda, R ;

Barlogie, B ;

Shaughnessy, J ;

Esumi, H .

ONCOGENE, 2005, 24 (46) :6936-6944

[42] ARK5 is a tumor invasion-associated factor downstream of Akt signaling [J].

Suzuki, A ;

Lu, H ;

Kusakai, GI ;

Kishimoto, A ;

Ogura, T ;

Esumi, H .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (08) :3526-3535

[43] Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family [J].

Suzuki, A ;

Kusakai, G ;

Kishimoto, A ;

Minegichi, Y ;

Ogura, T ;

Esumi, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 311 (01) :156-161

[44] ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation [J].

Suzuki, A ;

Kusakai, G ;

Kishimoto, A ;

Lu, J ;

Ogura, T ;

Esumi, H .

ONCOGENE, 2003, 22 (40) :6177-6182

[45] Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein [J].

Suzuki, A ;

Kusakai, G ;

Kishimoto, A ;

Lu, J ;

Ogura, T ;

Lavin, MF ;

Esumi, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (01) :48-53

[46] NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling [J].

Suzuki, Atsushi ;

Ogura, Tsutomu ;

Esumi, Hiroyasu .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (20) :13915-13921

[47] Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci [J].

Tsuchihara, Katsuya ;

Ogura, Tsutomu ;

Fujioka, Rumi ;

Fujii, Satoshi ;

Kuga, Wataru ;

Saito, Marie ;

Ochiya, Takahiro ;

Ochiai, Atsushi ;

Esumi, Hiroyasu .

CANCER SCIENCE, 2008, 99 (04) :677-682

[48] Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1 [J].

Wang, Ji-Wu ;

Imai, Yuzuru ;

Lu, Bingwei .

JOURNAL OF NEUROSCIENCE, 2007, 27 (03) :574-581

[49] LKB1 and AMPK in cell polarity and division [J].

Williams, Tyisha ;

Brenman, Jay E. .

TRENDS IN CELL BIOLOGY, 2008, 18 (04) :193-198

[50] Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells [J].

Woods, A ;

Dickerson, K ;

Heath, R ;

Hong, SP ;

Momcilovic, M ;

Johnstone, SR ;

Carlson, M ;

Carling, D .

CELL METABOLISM, 2005, 2 (01) :21-33

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