Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

被引：116

作者：

Gamrekelashvili, Jaba ^{[1
]}

Giagnorio, Roberto ^{[1
,2
]}

Jussofie, Jasmin ^{[3
,16
]}

Soehnlein, Oliver ^{[4
,5
,6
]}

Duchene, Johan ^{[4
]}

Briseno, Carlos G. ^{[7
]}

Ramasamy, Saravana K. ^{[8
]}

Krishnasamy, Kashyap ^{[1
]}

Limbourg, Anne ^{[9
]}

Kapanadze, Tamar ^{[1
,2
]}

Ishifune, Chieko ^{[10
]}

Hinkel, Rabea ^{[4
,11
]}

Radtke, Freddy ^{[12
]}

Strobl, Lothar J. ^{[13
]}

Zimber-Strobl, Ursula ^{[13
]}

Napp, L. Christian ^{[3
]}

Bauersachs, Johann ^{[3
]}

Haller, Hermann ^{[1
]}

Yasutomo, Koji ^{[10
]}

Kupatt, Christian ^{[4
,11
]}

Murphy, Kenneth M. ^{[7
,14
]}

Adams, Ralf H. ^{[8
]}

Weber, Christian ^{[4
,15
]}

Limbourg, Florian P. ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Dept Hypertens & Nephrol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat, D-30625 Hannover, Germany

[3] Hannover Med Sch, Dept Cardiol, D-30625 Hannover, Germany

[4] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, D-80336 Munich, Germany

[5] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

[6] German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany

[7] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[8] Max Planck Inst Mol Biomed, D-48149 Munster, Germany

[9] Hannover Med Sch, Dept Plast Hand & Reconstruct Surg, D-30625 Hannover, Germany

[10] Univ Tokushima, Grad Sch Med, Dept Immunol & Parasitol, Tokushima 7708503, Japan

[11] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 1, D-81675 Munich, Germany

[12] Ecole Polytech Fed Lausanne, Sch Life Sci, ISREC, CH-1015 Lausanne, Switzerland

[13] German Res Ctr Environm & Hlth GmbH, Helmholtz Zentrum Munchen, Res Unit Gene Vectors, D-81377 Munich, Germany

[14] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

[15] Cardiovasc Res Inst Maastricht CARIM, NL-6229 ER Maastricht, Netherlands

[16] Univ Klinikum Dusseldorf, Dept Cardiol, D-40225 Dusseldorf, Germany

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

关键词：

GREEN FLUORESCENT PROTEIN; ENDOTHELIAL-CELLS; DENDRITIC CELLS; VASCULAR NICHE; MACROPHAGES; DIFFERENTIATION; ANGIOGENESIS; ORCHESTRATE; SUBSETS; LIGAND;

D O I：

10.1038/ncomms12597

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

A population of monocytes, known as Ly6C(lo) monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6C(hi) monocytes into Ly6C(lo) monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.

引用

页数：14

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