ICE-related proteases in apoptosis

被引：148

作者：

Takahashi, A ^{[1
]}

Earnshaw, WC ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT CELL BIOL & ANAT,BALTIMORE,MD 21205

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(96)90010-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Apoptotic execution involves numerous enzymatic pathways, all of which appear to be triggered by the activation of one or more ICE-related proteases (IRPs). Considerable effort is currently being expended in the identification and functional characterization of the rapidly expanding superfamily of IRPs. Important questions that remain unsolved include the identity of the vertebrate IRP that triggers the apoptotic cascade and the identities of the crucial substrates whose cleavage results in the dramatic morphological changes during apoptosis.

引用

页码：50 / 55

页数：6

共 53 条

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