Obesity and the brain: a possible genetic link

被引：5

作者：

Bertram, Lars ^{[1
]}

Heekeren, Hauke ^{[2
,3
]}

机构：

[1] Max Planck Inst Mol Genet, Neuropsychiat Genet Grp, D-14195 Berlin, Germany

[2] Max Planck Inst Human Dev, D-14195 Berlin, Germany

[3] Free Univ Berlin, Dept Educ & Psychol, D-14195 Berlin, Germany

来源：

ALZHEIMERS RESEARCH & THERAPY | 2010年 / 2卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; FTO GENE; CHILDHOOD; VOLUME;

D O I：

10.1186/alzrt51

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined.

引用

页数：3

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