Tau pathology and neurodegeneration

被引:847
作者
Spillantini, Maria Grazia [1 ]
Goedert, Michel [2 ]
机构
[1] Univ Cambridge, Dept Clin Neurosci, John van Geest Ctr Brain Repair, Cambridge, England
[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
基金
英国医学研究理事会;
关键词
PAIRED HELICAL FILAMENTS; PROGRESSIVE SUPRANUCLEAR PALSY; MICROTUBULE-STABILIZING AGENT; DOMINANT ALZHEIMERS-DISEASE; MULTIPLE SYSTEM TAUOPATHY; AMYLOID-BETA DEPOSITION; TRANSGENIC MOUSE MODEL; PROTEIN-TAU; NEUROFIBRILLARY TANGLES; IN-VITRO;
D O I
10.1016/S1474-4422(13)70090-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human neurodegenerative diseases, collectively referred to as tauopathies. Dominantly inherited mutations in MAPT, the gene that encodes tau, cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is sufficient to cause neurodegeneration and dementia. However, most cases of tauopathy are not inherited in a dominant manner. The first tau aggregates form in a few nerve cells in discrete brain areas. These become self propagating and spread to distant brain regions in a prion-like manner. The prevention of tau aggregation and propagation is the focus of attempts to develop mechanism-based treatments for tauopathies.
引用
收藏
页码:609 / 622
页数:14
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