Reversible pH Lability of Cross-linked Vault Nanocapsules

被引：16

作者：

Yu, Marcella ^{[1
]}

Ng, Benny C. ^{[2
]}

Rome, Leonard H. ^{[3
,4
]}

Tolbert, Sarah H. ^{[2
,4
]}

Monbouquette, Harold G. ^{[1
,4
]}

机构：

[1] Univ Calif Los Angeles, Chem & Biomol Engn Dept, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 10期

关键词：

D O I：

10.1021/nl080536z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10 000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.

引用

页码：3510 / 3515

页数：6

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