MicroRNA-mediated control of macrophages and its implications for cancer

被引：198

作者：

Squadrito, Mario Leonardo ^{[1
]}

Etzrodt, Martin ^{[2
]}

De Palma, Michele ^{[1
]}

Pittet, Mikael J. ^{[2
]}

机构：

[1] Swiss Fed Inst Technol, EPFL, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1015 Lausanne, Switzerland

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Syst Biol, Boston, MA 02114 USA

来源：

TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 07期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

miRNA; inflammation; monocyte; tumor-associated macrophage; cancer; TUMOR-ASSOCIATED MACROPHAGES; NF-KAPPA-B; DENDRITIC CELLS; IN-VIVO; ALTERNATIVE ACTIVATION; FUNCTIONAL MICRORNAS; POLARIZATION; SUBSETS; METASTASIS; SUPPRESSOR;

D O I：

10.1016/j.it.2013.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.

引用

收藏

页码：350 / 359

页数：10

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