Electronic and Steric Effects in Binding of Deep Cavitands

被引：29

作者：

Hooley, Richard J.

Shenoy, Siddhartha R.

Rebek, Julius, Jr. ^{[1
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 23期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/ol8022775

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A deep, self-folding cavitand responds to minor electronic differences between suitably sized adamantane guests. Binding constants range from < 0.5 to 4000 M-1 for guests as similar as 1-bromoadamantane and 1-cyanoadamantane. The barriers to guest exchange also vary up to 3 kcal mol(-1).

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收藏

页码：5397 / 5400

页数：4

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