Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy

被引：337

作者：

Feng, Wei ^{[1
]}

Chen, Liang ^{[1
]}

Qin, Ming ^{[1
]}

Zhou, Xiaojun ^{[2
]}

Zhang, Qianqian ^{[1
]}

Miao, Yingke ^{[1
]}

Qiu, Kexin ^{[2
]}

Zhang, Yanzhong ^{[1
]}

He, Chuanglong ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[2] Donghua Univ, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

WALLED CARBON NANOTUBES; IN-VIVO; DRUG-DELIVERY; POLYPYRROLE NANOPARTICLES; WS2; NANOSHEETS; CONVERSION; GRAPHENE; ABLATION; AGENT; OXIDE;

D O I：

10.1038/srep17422

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and investigate their potential for photothermal ablation of cancer cells. MoS2 nanoflakes are synthesized via a facile hydrothermal method and then modified with lipoic acid-terminated polyethylene glycol (LA-PEG), endowing the obtained nanoflakes with high colloidal stability and very low cytotoxicity. Upon irradiation with near infrared (NIR) laser at 808 nm, the nanoflakes showed powerful ability of inducing higher temperature, good photothermal stability and high photothermal conversion efficiency. The in vitro photothermal effects of MoS2-PEG nanoflakes with different concentrations were also evaluated under various power densities of NIR 808-nm laser irradiation, and the results indicated that an effective photothermal killing of cancer cells could be achieved by a low concentration of nanoflakes under a low power NIR 808-nm laser irradiation. Furthermore, cancer cell in vivo could be efficiently destroyed via the photothermal effect of MoS2-PEG nanoflakes under the irradiation. These results thus suggest that the MoS2-PEG nanoflakes would be as promising photothermal agents for future photothermal cancer therapy.

引用

页数：13

共 56 条

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