The acylation stimulating protein pathway: Clinical implications

被引:18
作者
Cianflone, K
机构
[1] McGill U. Prev. of Cardiovasc. Dis., McGill University, Montreal, Que.
[2] McGill U. Prev. of Cardiovasc. Dis., Royal Victoria Hospital, 687 Pine Avenue West, Montreal
关键词
acylation stimulating protein; adipose; triglyceride synthesis; glucose transport; differentiation; complement C3a;
D O I
10.1016/S0009-9120(97)00011-8
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objectives: The present review will focus particularly on acylation stimulating protein (ASP) and its role in adipose tissue. Two issues will be addressed (1) in vitro biochemical characterization of ASP in cell culture studies, and (2) in vivo clinical relevance for normal physiology and in pathological conditions. Conclusions: Fat is in! There can be no question that in recent years fat tissue has become recognized as more than just a passive storage site. It is a metabolically active tissue that, under normal conditions, allows the efficient clearance of triglyceride and glucose for storage as energy. Under abnormal conditions, adipose tissue dysfunction is associated with obesity, diabetes and coronary heart disease. Adipose tissue function may be controlled by many factors.
引用
收藏
页码:301 / 312
页数:12
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