The acylation stimulating protein pathway: Clinical implications

Objectives: The present review will focus particularly on acylation stimulating protein (ASP) and its role in adipose tissue. Two issues will be addressed (1) in vitro biochemical characterization of ASP in cell culture studies, and (2) in vivo clinical relevance for normal physiology and in pathological conditions. Conclusions: Fat is in! There can be no question that in recent years fat tissue has become recognized as more than just a passive storage site. It is a metabolically active tissue that, under normal conditions, allows the efficient clearance of triglyceride and glucose for storage as energy. Under abnormal conditions, adipose tissue dysfunction is associated with obesity, diabetes and coronary heart disease. Adipose tissue function may be controlled by many factors.