Nucleotide analogues to investigate RNA structure and function

被引：32

作者：

Das, SR

Fong, R

Piccirilli, JA

机构：

[1] Univ Chicago, Dept Biochem & Mol Biol, Howard Hughes Med Inst, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Chem, Howard Hughes Med Inst, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 06期

关键词：

D O I：

10.1016/j.cbpa.2005.10.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA plays an essential cellular role in nearly every aspect of the transmission and expression of genetic information, including regulatory roles that have significance for cellular development. Access to RNA bearing synthetic modifications has allowed biological chemists to probe deep into the inner workings of cellular processes. Here, we describe recent advances in harnessing the power of nucleotide analogues to obtain mechanistic and biological insights into RNA structure, function and dynamics.

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页码：585 / 593

页数：9

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