The Challenge of Finding a Cure for HIV Infection

被引：690

作者：

Richman, Douglas D. ^{[1
]}

Margolis, David M. ^{[2
]}

Delaney, Martin ^{[3
]}

Greene, Warner C. ^{[4
]}

Hazuda, Daria ^{[5
]}

Pomerantz, Roger J. ^{[6
,7
]}

机构：

[1] San Diego VA Healthcare Syst, La Jolla, CA 92093 USA

[2] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

[3] Project Inform, San Francisco, CA 94103 USA

[4] Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

[5] Merck & Co Inc, West Point, PA 19486 USA

[6] Johnson & Johnson Corp, Yardley, PA 19067 USA

[7] Tibotec Pharmaceut Inc, Yardley, PA 19067 USA

来源：

SCIENCE | 2009年 / 323卷 / 5919期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; REPLICATION-COMPETENT HIV; CENTRAL-NERVOUS-SYSTEM; NF-KAPPA-B; CELLULAR RESERVOIRS; ANTIVIRAL THERAPY; P-TEFB; LATENCY;

D O I：

10.1126/science.1165706

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4(+) lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.

引用

页码：1304 / 1307

页数：4

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