Fast and highly regioselective allylation of indole and pyrrole compounds by allyl alcohols using Ru-sulfonate catalysts

被引：81

作者：

Zaitsev, Alexey B. ^{[1
]}

Gruber, Stefan ^{[1
]}

Pluess, Pascal A. ^{[1
]}

Pregosin, Paul S. ^{[1
]}

Veiros, Luis F. ^{[2
]}

Woerle, Michael ^{[1
]}

机构：

[1] ETHZ, Inorgan Chem Lab, CH-8093 Zurich, Switzerland

[2] Univ Tecn Lisboa, Ctr Quim Estrutural, Inst Super Tecn, P-1049001 Lisbon, Portugal

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 35期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1021/ja804379k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New Ru-sulfonate catalysts have been synthesized and shown to very rapidly allylate indole and pyrrole compounds using allyl alcohols as substrates. The observed regioselectivity is exceptionally high (up to 100% of the branched isomer). Density functional theory calculations explain these results.

引用

页码：11604 / +

页数：3

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