Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

被引：801

作者：

You, Jueng Soo

Jones, Peter A. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Dept Urol, Los Angeles, CA 90089 USA

来源：

CANCER CELL | 2012年 / 22卷 / 01期

关键词：

HISTONE DEACETYLASE INHIBITORS; DNA METHYLATION; TUMOR-SUPPRESSOR; SWI/SNF COMPLEX; ABERRANT EXPRESSION; FREQUENT MUTATIONS; STEM-CELLS; TET FAMILY; CHROMATIN; PROTEINS;

D O I：

10.1016/j.ccr.2012.06.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic and genetic alterations have long been thought of as two separate mechanisms participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands of human cancers has been the unexpected discovery of many inactivating mutations in genes that control the epigenome. These mutations have the potential to disrupt DNA methylation patterns, histone modifications, and nucleosome positioning and hence, gene expression. Genetic alteration of the epigenome therefore contributes to cancer just as epigenetic process can cause point mutations and disable DNA repair functions. This crosstalk between the genome and the epigenome offers new possibilities for therapy.

引用

页码：9 / 20

页数：12

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