Molecular design of glutathione-derived biochemical probes targeting the GS-X pump

被引:19
作者
Furuta, K
Tomokiyo, K
Kuo, MT
Ishikawa, T
Suzuki, M
机构
[1] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan
[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA
[3] Univ Texas, MD Anderson Canc Ctr, Dept Expt Pediat, Sect Mol Therapeut, Houston, TX 77030 USA
关键词
D O I
10.1016/S0040-4020(99)00375-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The syntheses of novel glutathione derivatives as photoaffinity and fluorescent biochemical probes for the GS-X pump are described. GIF-0017, an S-alkylated glutathione derivative with a benzophenone photophore, competitively inhibits the transport of leukotriene C-4 by the GS-X pump with an IC50 value of 0.40 mu M, indicating the existence of strong interaction between the probe molecule and the GS-X pump. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7529 / 7540
页数:12
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