Molecular design of glutathione-derived biochemical probes targeting the GS-X pump

被引：19

作者：

Furuta, K

Tomokiyo, K

Kuo, MT

Ishikawa, T

Suzuki, M

机构：

[1] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan

[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Expt Pediat, Sect Mol Therapeut, Houston, TX 77030 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(99)00375-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of novel glutathione derivatives as photoaffinity and fluorescent biochemical probes for the GS-X pump are described. GIF-0017, an S-alkylated glutathione derivative with a benzophenone photophore, competitively inhibits the transport of leukotriene C-4 by the GS-X pump with an IC50 value of 0.40 mu M, indicating the existence of strong interaction between the probe molecule and the GS-X pump. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7529 / 7540

页数：12

共 49 条

[21] Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells [J].