Copper-catalyzed cycloisomerizations of 5-En-1-yn-3-ols

被引：41

作者：

Fehr, C ^{[1
]}

Farris, I ^{[1
]}

Sommer, H ^{[1
]}

机构：

[1] Firmenich Co, Corp R&D Div, CH-1211 Geneva, Switzerland

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 09期

关键词：

D O I：

10.1021/ol0603864

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Cu(I)-catalyzed cycloisomerization of tertiary 5-en-1-yn-3-ols with an 1,2-alkyl shift affords stereoselectively tri- and tetracyclic compounds of high molecular complexity. These results are in agreement with a mechanism in which the cyclopropanation precedes the rearrangement.

引用

页码：1839 / 1841

页数：3

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