Evolution of human endogenous retroviral sequences: a conceptual account

被引：85

作者：

Blikstad, V. ^{[1
]}

Benachenhou, F. ^{[1
]}

Sperber, G. O. ^{[2
]}

Blomberg, J. ^{[1
]}

机构：

[1] Uppsala Univ, Acad Hosp, Dept Med Sci, Virol Sect, S-75185 Uppsala, Sweden

[2] Uppsala Univ, Dept Neurosci Physiol, Uppsala, Sweden

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 21期

关键词：

Endogenous retrovirus; evolution; lateral transfer; virulence; vertebrate genome; bioinformatics; sequence recognition;

D O I：

10.1007/s00018-008-8495-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous retroviruses (ERVs) most likely are remnants of ancient retroviral infections. ERVs preserve functions of exogenous retroviruses to a varying extent, and can be parasites, symbionts or more or less neutral genetic 'junk'.Their evolution has two facets, pre- and post-endogenization. Although the two are not clearly separated, the first pertains to retroviral evolution in general and the second to the fate of repetitive DNA and the evolution of the host organism and its genome. The study of ERVs provides much material for the understanding of retroviral evolution. This sequence archive reflects the history of successes and shortcomings of antiviral resistance, but also of strategic evolutionary decisions regarding genome organization and new gene acquisition. This review discusses retroviral evolution illustrated through HERVs, bioinformatic prerequisites for ERV studies, the endogenization process and HERV evolution post-endogenization, including relation to disease. (Part of a Multi-author Review).

引用

页码：3348 / 3365

页数：18

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