Dynamic Integration of Splicing within Gene Regulatory Pathways

被引：338

作者：

Braunschweig, Ulrich ^{[1
]}

Gueroussov, Serge ^{[1
,2
]}

Plocik, Alex M. ^{[3
]}

Graveley, Brenton R. ^{[3
]}

Blencowe, Benjamin J. ^{[1
,2
]}

机构：

[1] Univ Toronto, Donnelly Ctr, Banting & Best Dept Med Res, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

[3] Univ Connecticut, Ctr Hlth, Inst Syst Genom, Dept Genet & Dev Biol, Farmington, CT 06030 USA

来源：

CELL | 2013年 / 152卷 / 06期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

PRE-MESSENGER-RNA; C-TERMINAL DOMAIN; CELL-FREE FORMATION; SR-LIKE PROTEIN; POLYMERASE-II; NUCLEAR EXPORT; HISTONE H3; LYSINE; 9; COUPLING TRANSCRIPTION; CHROMATIN SIGNATURES;

D O I：

10.1016/j.cell.2013.02.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.

引用

页码：1252 / 1269

页数：18

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