The agrin/muscle-specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junction

被引：52

作者：

Liyanage, Y

Hoch, W

Beeson, D

Vincent, A ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England

[2] Max Planck Inst Dev Biol, Tubingen, Germany

来源：

MUSCLE & NERVE | 2002年 / 25卷 / 01期

关键词：

agrin congenital myasthenic syndromes; muscle-specific kinase (MuSK); myasthenia gravis; seronegative myasthenia; neuromuscular junction; neuromuscular transmission;

D O I：

10.1002/mus.1218

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The increasing understanding of the structural complexity of the neuromuscular junction (NMJ), and the processes that are important in its development, suggests many possible new disease targets. Here, we summarize briefly the genetic and autoimmune disorders that affect neuromuscular transmission, and the identified targets, including new evidence that antibodies to muscle-specific receptor tyrosine kinase (MuSK) are involved in the pathogenesis of acetylcholine receptor (AChR) antibody-negative myasthenia gravis. We then review the development of the NMJ, focusing on the important roles of nerve-derived agrin and MuSK in clustering of AChRs and other essential components of the NMJ. (C) 2002 John Wiley & Sons, Inc.

引用

页码：4 / 16

页数：13

共 127 条

[11] ROLE FOR DYSTROPHIN-ASSOCIATED GLYCOPROTEINS AND UTROPHIN IN AGRIN-INDUCED ACHR CLUSTERING [J].