Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases

被引：584

作者：

Schneider, David S. ^{[1
]}

Ayres, Janelle S. ^{[1
]}

机构：

[1] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2432

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A host can evolve two types of defence mechanism to increase its fitness when challenged with a pathogen: resistance and tolerance. Immunology is a well-defined field in which the mechanisms behind resistance to infection are dissected. By contrast, the mechanisms behind the ability to tolerate infections are studied in a less methodical manner. In this Opinion, we provide evidence that animals have specific tolerance mechanisms and discuss their potential clinical impact. It is important to distinguish between these two defence mechanisms because they have different pathological and epidemiological effects. An increased understanding of tolerance to pathogen infection could lead to more efficient treatments for infectious diseases and a better description of host-pathogen interactions.

引用

页码：889 / 895

页数：7

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