The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

被引：305

作者：

Unsicker, Klaus ^{[1
]}

Spittau, Bjoern ^{[1
]}

Krieglstein, Kerstin ^{[1
]}

机构：

[1] Univ Freiburg, Dept Mol Embryol, D-79104 Freiburg, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2013年 / 24卷 / 04期

关键词：

Cardiovascular disease; Inflammation; Metabolism; Cancer; Neurotrophic factors; GROWTH-DIFFERENTIATION FACTOR-15; ACTIVATED GENE NAG-1; SUPERFAMILY MEMBER; SERUM CONCENTRATIONS; INTEGRIN ACTIVATION; MATERNAL SERUM; CANCER CELLS; EXPRESSION; MIC-1; GDF-15;

D O I：

10.1016/j.cytogfr.2013.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-beta superfamily, which is widely distributed in mammalian tissues and has been shown to play multiple roles in various pathologies, including inflammation, cancer, cardiovascular diseases, and obesity. GDF-15 serum levels are a highly reliable predictor of disease progression. Both the anti-tumorigenic potential of GDF-15 and its capacity to promote metastasis have been documented for a large variety of cancers, yet its opposing functions, which are typical for members of the TGF-beta superfamily, have only partly been resolved on the molecular level. Knowledge on physiological functions in the non-diseased organism is scarce. In the nervous system GDF-15 knockout analyses have revealed that GDF-15 is essential for the postnatal maintenance of various neuron populations. When applied exogenously GDF-15 is a powerful factor for promoting survival of developing and lesioned neurons in vitro and in vivo. Receptor activation by GDF- has only been partially resolved. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：373 / 384

页数：12

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