Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype

被引：12

作者：

Gröschel, B

Meier, C

Zehner, R

Cinatl, J

Doerr, HW

Cinatl, J

机构：

[1] Univ Frankfurt, Inst Med Virol, D-60528 Frankfurt, Germany

[2] Univ Wurzburg, Inst Organ Chem, D-8700 Wurzburg, Germany

[3] Univ Frankfurt, Ctr Legal Med, D-6000 Frankfurt, Germany

[4] Univ Frankfurt, Dept Hematol & Oncol, Ctr Pediat, D-6000 Frankfurt, Germany

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9(r)AZT(250)). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9(r)AZT(250) cells, which exert decreased thymidine kinase (TK) gene expression.

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页码：933 / 936

页数：4

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