Cyclic saligenyl phosphotriesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) - A new pro-nucleotide approach

被引：48

作者：

Meier, C ^{[1
]}

Lorey, M ^{[1
]}

DeClercq, E ^{[1
]}

Balzarini, J ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00597-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new pro-nucleotide approach for d4TMP 2 based on cycloSal-d4TMP 3a-d is described. Phosphotriesters 3 release d4TMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited high biological activity against HIV-1/HIV-2 in CEM cells which was retained in CEM TK- cells. (C) 1997, Published by Elsevier Science Ltd.

引用

页码：99 / 104

页数：6

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