Increase of the anti-HIV activity of D4T in human T-cell culture by the use of the sate pronucleotide approach

被引：42

作者：

Girardet, JL

Perigaud, C

Aubertin, AM

Gosselin, G

Kirn, A

Imbach, JL

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,URA 488,F-34095 MONTPELLIER,FRANCE

[2] FAC MED STRASBOURG,INST VIROL,INSERM,U74,F-67000 STRASBOURG,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 24期

关键词：

D O I：

10.1016/0960-894X(95)00525-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The bis(S-acetyl-2-thioethyl) phosphotriester derivative of 2',3'-didehydro-2',3'-dideoxythymidine has been synthesized and evaluated for its inhibitory effects on the replication of HIV-1 in several cell culture systems, This pronucleotide showed potent anti-HIV activity and proved to be significantly superior to the parent nucleoside with regard to the antiviral efficiency.

引用

页码：2981 / 2984

页数：4

共 16 条

[1] PRODRUGS OF ANALOGS OF NUCLEIC-ACID COMPONENTS [J].