The fibroblast-populated collagen matrix as a model of wound healing: a review of the evidence

被引：132

作者：

Carlson, MA

Longaker, MT

机构：

[1] Omaha VA Med Ctr, Omaha, NE 68105 USA

[2] Univ Nebraska, Med Ctr, Dept Surg, Omaha, NE USA

[3] Stanford Univ, Dept Surg, Stanford, CA 94305 USA

来源：

WOUND REPAIR AND REGENERATION | 2004年 / 12卷 / 02期

关键词：

D O I：

10.1111/j.1067-1927.2004.012208.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fibroblast-populated collagen matrix (FPCM) has been utilized as an in vitro model of wound healing for more than 2 decades. It offers a reasonable approximation of the healing wound during the phases of established granulation tissue and early scar. The gross and microscopic morphology of the FPCM and the healing wound are similar at analogous phases. The processes of proliferation, survival/apoptosis, protein synthesis, and contraction act in similar directions in these two models, and the response to exogenous agents also is consistent between them. If its limitations are respected, then the FPCM can be used as a model of the healing wound.

引用

页码：134 / 147

页数：14

共 182 条

[61] Transforming growth factors beta 1, beta 2, and beta 3 and their receptors are differentially regulated during normal and impaired wound healing [J].