An original emission tomograph for in vivo brain imaging of small animals

被引：16

作者：

Ochoa, AV ^{[1
]}

Ploux, L ^{[1
]}

Mastrippolito, R ^{[1
]}

Charon, Y ^{[1
]}

Laniece, P ^{[1
]}

Pinot, L ^{[1
]}

Valentin, L ^{[1
]}

机构：

[1] UNIV PARIS 07,GRP MODELISAT PHYS & INTERFACES BIOL,F-75005 PARIS,FRANCE

来源：

IEEE TRANSACTIONS ON NUCLEAR SCIENCE | 1997年 / 44卷 / 04期

关键词：

D O I：

10.1109/23.632717

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The principle of a new tomograph (TOHR) dedicated for small volume analysis with very high resolution is presented in this paper. We use uncorrelated multi-photon (X or gamma rays) radioisotopes and a large solid angle focusing collimator to produce tomographic images without a reconstruction algorithm. With this device, detection efficiency and resolution are independent and submillimeter resolution can be achieved. A feasibility study shows that collimators made with a stack of chemically etched plates can achieve the predicted performances of TOHR. We discuss its potential in rat brain tomography by simulating a realistic neuropharmacological experiment using a 1.4 mm resolution prototype of the TOHR under development.

引用

页码：1533 / 1537

页数：5

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